Emerging trends in aesthetic dermatology include new scientifically based cosmeceutical skin care products. Over the last few years, there has been increased interest in new approaches to aesthetic dermatology. These developments include growth factor technology and peptides, which induce collagen remodeling, as well as peptides that attempt to inhibit neuromuscular transmission. In addition, new high-potency antioxidant cocktails also are being formulated in an attempt to provide strong UV-induced cell protection. Gene modulation products that attempt to down-regulate the genetic cellular markers of aging by employing gene chip technology represent a novel approach to topical skin care as well. This special Cornell University issue of Cosmetic Dermatology® explores several of these novel cosmeceutical approaches.