Pigmented lesions are common among patients presenting to dermatologists. Fortunately, a large arsenal of light-based technology is available for the reduction and removal of these lesions. By developing a comprehensive understanding of the microanatomy of dyschromia, physicians can optimize protocols based on principles of laser-tissue interactions and reports in the literature. This article will examine the author’s experience and preferences in treating specific types of pigmented lesions with various lasers and light devices.