Soft tissue fillers are becoming increasingly important as nonsurgical treatment options for patients seeking to ameliorate the appearance of facial aging. Radiesse®, a calcium hydroxylapatite (CaHA) compound in an aqueous gel carrier, is gaining popularity as a nonsurgical facial contouring agent. We examine the use of CaHA for cheek augmentation, providing an overview of available soft tissue fillers, as well as a description of CaHA, its clinical applications, and injection techniques for facial contouring. Additionally, we discuss which patients and treatment areas are optimal candidates for this longer-lasting soft tissue filler.