Eczema is a skin disease associated with many cosmetic concerns for patients, including feelings of embarrassment and stigmatization as well as challenges to employment opportunities and interpersonal relationships. Natural treatment of eczema currently is of considerable interest among dermatologists. Classic homeopathic medicine can be used as a holistic natural treatment of atopic dermatitis (AD) and irritant contact eczema. This article describes the treatment regimens and clinical outcomes of 6 patients who underwent homeopathic therapy for AD or irritant contact dermatitis. Potential advantages of incorporating homeopathic medicine in the conventional dermatology practice include low cost, availability, ease of administration, patient acceptability, and reduction in topical steroid use. Additionally, patients also may see improvements in symptoms caused by seemingly unrelated medical conditions when their eczema is treated holistically with homeopathic medicine.