Retinaldehyde, a member of the retinoid family, may be beneficial when combined with the antiinflammatory properties of dextran sulfate, along with hesperidin methyl chalcone, which reinforces vessel walls. The purpose of this study was to assess the usefulness and tolerability of a topical skin care regimen as an adjunct to treatment of facial rosacea when using a cream containing retinaldehyde 0.05%, dextran sulfate 0.3%, and hesperidin methyl chalcone 0.2% during a 6-month period in patients suffering from facial rosacea.