In this article, the authors describe the efficacy of a natural secretion of Cryptomphalus aspersa (SCA) in cutaneous photoaging. This placebo-free, open-label study comprised 15 women exhibiting facial photoaging. Treatment with SCA for 3 months induced a significant reduction in photoaging on the Glogau scale. Silicone replica analysis showed significant improvements in skin roughness and wrinkle depth. Histopathological analysis revealed a marked improvement in both dermal and epidermal architecture, as well as epidermal proliferation and the percentage of cutaneous area covered by microvessels. In summary, treatment with SCA for 3 months resulted in a significant improvement of the clinical and histological signs of photoaging, and these correlated with both subjective and objective assessments of chronic photodamage.