Vascular lesions, similar to varicose veins, telangiectases, rosacea, hemangiomas, and port-wine stains, are common and can affect up to 5% of the adult population. Although they typically are not painful, vascular lesions can have a great impact on the patient’s quality of life. Leg lesions can cause symptoms such as aching, discomfort, and muscle cramps that primarily affect a patient’s health-related quality of life, while facial lesions often lead to psychologic discomfort and feelings of embarrassment, anxiety, low self-esteem, and antisocial behavior. From this perspective, it is apparent that the treatment of vascular lesions is more than just a cosmetic concern; it also has a high degree of medical relevance.