There is a decrease in normal collagen in aged and sun-damaged skin. Neocollagenesis can promote a more youthful appearance. A key target in the mitigation of the pathophysiology of photoaging is fibroblasts. Various therapeutic modalities can be employed, including topical retinoids, dermabrasion, radiofrequency or ultrasound energy, and filler injections. This review focuses on the molecular-level effects of lasers and light sources to activate fibroblasts. Fractional ablative and nonablative resurfacing lasers are the gold standard for stimulating aged fibroblasts and inducing neocollagenesis; however, other laser and light modalities can be employed to activate quiescent fibroblasts.