This comparative, double-blinded study included 62 subjects and assessed the efficacy and tolerance of 2 antiwrinkle facial creams: Alyria Intense Wrinkle Correction/Wrinkle Repair and StriVectin-SD®, a popular product currently on the market. Volunteers applied the products twice daily during a period of 3 months. While both treatments were well tolerated and well perceived by the majority of subjects, clear differences were observed in the results. The improvements achieved with Alyria Intense Wrinkle Correction/Wrinkle Repair appeared more significant than those achieved with StriVectin-SD, primarily in the number of wrinkles, the appearance of deeper wrinkles, and the surface area and total length of wrinkles.