The aging process leads to changes that occur in all layers of the skin and subcutaneous tissue as well as the underlying muscle and bone. The evolution of injectables and development of resurfacing technologies have allowed patients to age gracefully, especially with regard to aesthetic improvement of the face and neck; however, there have been few studies that address changes in the aging hand or ways to correct these changes with minimally invasive procedures. We discuss techniques for successful hand rejuvenation with frequently used injectables (off-label uses).