Patients commonly seek treatment in cosmetic practices for rejuvenation of the lips and lower face. Over the last 15 years, cosmetic procedures for the lips and lower face have seen improvements through increased technology. As with all procedures, some physicians more commonly perform nonsurgical treatments, while others are more surgically oriented. Anyone can inject filler, but to be masterful, physicians must have an advanced understanding of the facial anatomy and aging process as well as an appreciation of the art and science of injectables, which only comes through experience. When treating the lips, each patient presents a unique challenge, and physicians who understand the nuances of lips not only take great pride in their rejuvenation techniques but also produce predictable outcomes.