This study was designed to evaluate the tolerability and efficacy of a moisturizing cream containing kinetin (N6-furfuryladenine) 0.1% for improving the signs of age-related changes in facial and neck skin. Eighteen patients (age range, 21–64 years) with mild to moderate photodamage were enrolled in the study. Subjects applied kinetin 0.1% cream combined with sunscreen (sun protection factor 30) twice daily to the face and neck, once in the morning and again in the evening 1 hour before bedtime, for up to 24 weeks. Evaluations included patient assessment of overall skin improvement and improvement in roughness, laxity, mottled hyperpigmentation, fine wrinkles, texture, and blotchiness. VISIA®, a complexion-analysis system, was used to provide an objective measurement of porphyrins, pores, wrinkles, visible spots, and UV spots. Ultrasound (DermaScan™) was used to measure skin collagen density at each visit. Patients were assessed at baseline and at 6, 12, 18, and 24 weeks. Results suggest kinetin 0.1% cream combined with sunscreen may be an effective treatment option for improving skin appearance in people with mild to moderate photodamage without the cutaneous adverse effects associated with other commonly used antiaging products, such as retinoids.