New products constantly are being developed to help ease the ravages of time and aging. One of these is Radiesse, an injectable compound of calcium hydroxylapatite suspended in an aqueous gel. Radiesse is an excellent filler for nasolabial folds, marionette lines, oral commissurae, and deep rhytides. The technique for administering Radiesse is subdermal injection, most commonly at the junction of deep dermis and subcutaneous tissue. On withdrawal of the syringe, small aliquots of material are deposited uniformly along the plane. Subsequent injections may be made through the same entry point. Radiesse is considered a semipermanent filler. Most recent clinical data have reported between 30% and 100% correction at 1 year. In my clinical experience, correction duration of at least 1 year results in high patient satisfaction. However, booster injections may be required during this period for patients with deep defects. Regardless of the exact correction duration, this injectable compound holds promise for long-term soft tissue augmentation of lines, depressions, scars, and facial defects.